ATAD2-ERBB4 Fusion FISH Probe
The ATAD2-ERBB4 Fusion FISH Probe is used to confirm a fusion of the ATAD2 and ERBB4 genes. The fusion of the ATAD2 and ERBB4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ATAD2-ERBB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-RERE | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-REOR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-REGO | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-REGR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-REAQ | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-ORRE | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-OROR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-ORGO | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GORE | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GOOR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GOGO | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GOGR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GRRE | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GROR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GRGO | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GRGR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-AQRE | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-AQOR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-AQGO | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-AQGR | 20 (40 μL) | 200 μL |
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| ATAD2-ERBB4-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB4 Gene Summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 4
Chromosome: CHR2: 212240441 -213403352
Locus: 2q34
ATAD2 Gene Summary
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Family, AAA Domain Containing 2
Chromosome: CHR8: 124332090 -124408705
Locus: 8q24.13
Gene Diseases
The ATAD2 ERBB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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