ASXL1-XKR7 Fusion FISH Probe
The ASXL1-XKR7 Fusion FISH Probe is used to confirm a fusion of the ASXL1 and XKR7 genes. The fusion of the ASXL1 and XKR7 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASXL1-XKR7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-RERE | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-REOR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-REGO | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-REGR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-REAQ | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-ORRE | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-OROR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-ORGO | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GORE | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GOOR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GOGO | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GOGR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GRRE | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GROR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GRGO | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GRGR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-AQRE | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-AQOR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-AQGO | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-AQGR | 20 (40 μL) | 200 μL |
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| ASXL1-XKR7-20-AQAQ | 20 (40 μL) | 200 μL |
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ASXL1 Gene Summary
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Additional Sex Combs Like 1, Transcriptional Regulator
Chromosome: CHR20: 30946146 -31027122
Locus: 20q11.21
XKR7 Gene Summary
The XK Related 7 (XKR7) gene is located on chr20 :30555804-30586256 at 20q11.21.
Gene Name: XK Related 7
Chromosome: CHR20: 30555804 -30586256
Locus: 20q11.21
Gene Diseases
The ASXL1 XKR7 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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