ASXL1-DEFB118 Fusion FISH Probe
The ASXL1-DEFB118 Fusion FISH Probe is used to confirm a fusion of the ASXL1 and DEFB118 genes. The fusion of the ASXL1 and DEFB118 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASXL1-DEFB118-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-RERE | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-REOR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-REGO | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-REGR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-REAQ | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-ORRE | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-OROR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-ORGO | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GORE | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GOOR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GOGO | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GOGR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GRRE | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GROR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GRGO | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GRGR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-AQRE | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-AQOR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-AQGO | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-AQGR | 20 (40 μL) | 200 μL |
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| ASXL1-DEFB118-20-AQAQ | 20 (40 μL) | 200 μL |
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DEFB118 Gene Summary
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]
Gene Name: Defensin Beta 118
Chromosome: CHR20: 29956420 -29961705
Locus: 20q11.21
ASXL1 Gene Summary
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Additional Sex Combs Like 1, Transcriptional Regulator
Chromosome: CHR20: 30946146 -31027122
Locus: 20q11.21
Gene Diseases
The ASXL1 DEFB118 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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