ASPH-RSF1 Fusion FISH Probe
The ASPH-RSF1 Fusion FISH Probe is used to confirm a fusion of the ASPH and RSF1 genes. The fusion of the ASPH and RSF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASPH-RSF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-RERE | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-REOR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-REGO | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-REGR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-REAQ | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-ORRE | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-OROR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-ORGO | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GORE | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GOOR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GOGO | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GOGR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GRRE | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GROR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GRGO | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GRGR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-AQRE | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-AQOR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-AQGO | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-AQGR | 20 (40 μL) | 200 μL |
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| ASPH-RSF1-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
RSF1 Gene Summary
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Gene Name: Remodeling And Spacing Factor 1
Chromosome: CHR11: 77377273 -77531880
Locus: 11q14.1
Gene Diseases
The ASPH RSF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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