ASPH-RP1 Fusion FISH Probe
The ASPH-RP1 Fusion FISH Probe is used to confirm a fusion of the ASPH and RP1 genes. The fusion of the ASPH and RP1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASPH-RP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-RERE | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-REOR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-REGO | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-REGR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-OROR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GORE | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GROR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ASPH-RP1-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
RP1 Gene Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
Gene Name: RP1, Axonemal Microtubule Associated
Chromosome: CHR8: 55528626 -55543394
Locus: 8q11.23-q12.1
Gene Diseases
The ASPH RP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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