ASPH-EIF4EBP1 Fusion FISH Probe
The ASPH-EIF4EBP1 Fusion FISH Probe is used to confirm a fusion of the ASPH and EIF4EBP1 genes. The fusion of the ASPH and EIF4EBP1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASPH-EIF4EBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ASPH-EIF4EBP1-20-AQAQ | 20 (40 μL) | 200 μL |
|
ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
EIF4EBP1 Gene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Chromosome: CHR8: 37888019 -37917883
Locus: 8p11.23
Gene Diseases
The ASPH EIF4EBP1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|