ASPH-DCLK1 Fusion FISH Probe
The ASPH-DCLK1 Fusion FISH Probe is used to confirm a fusion of the ASPH and DCLK1 genes. The fusion of the ASPH and DCLK1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASPH-DCLK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-RERE | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-REOR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-REGO | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-REGR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-OROR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GORE | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GROR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ASPH-DCLK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ASPH Gene Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Gene Name: Aspartate Beta-hydroxylase
Chromosome: CHR8: 62413114 -62627199
Locus: 8q12.3
DCLK1 Gene Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
Gene Name: Doublecortin Like Kinase 1
Chromosome: CHR13: 36342788 -36705514
Locus: 13q13.3
Gene Diseases
The ASPH DCLK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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