ASH1L-NSL1 Fusion FISH Probe
The ASH1L-NSL1 Fusion FISH Probe is used to confirm a fusion of the ASH1L and NSL1 genes. The fusion of the ASH1L and NSL1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASH1L-NSL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-RERE | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-REOR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-REGO | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-REGR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-REAQ | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-ORRE | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-OROR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-ORGO | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GORE | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GOOR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GOGO | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GOGR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GRRE | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GROR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GRGO | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GRGR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-AQRE | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-AQOR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-AQGO | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-AQGR | 20 (40 μL) | 200 μL |
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| ASH1L-NSL1-20-AQAQ | 20 (40 μL) | 200 μL |
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NSL1 Gene Summary
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Gene Name: NSL1, MIS12 Kinetochore Complex Component
Chromosome: CHR1: 212899494 -212965139
Locus: 1q32.3
ASH1L Gene Summary
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]
Gene Name: ASH1 Like Histone Lysine Methyltransferase
Chromosome: CHR1: 155305051 -155532324
Locus: 1q22
Gene Diseases
The ASH1L NSL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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