ASCC1-CDH23 Fusion FISH Probe
The ASCC1-CDH23 Fusion FISH Probe is used to confirm a fusion of the ASCC1 and CDH23 genes. The fusion of the ASCC1 and CDH23 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASCC1-CDH23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-RERE | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-REOR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-REGO | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-REGR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-REAQ | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-ORRE | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-OROR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-ORGO | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GORE | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GOOR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GOGO | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GOGR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GRRE | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GROR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GRGO | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GRGR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-AQRE | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-AQOR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-AQGO | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-AQGR | 20 (40 μL) | 200 μL |
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| ASCC1-CDH23-20-AQAQ | 20 (40 μL) | 200 μL |
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ASCC1 Gene Summary
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Activating Signal Cointegrator 1 Complex Subunit 1
Chromosome: CHR10: 73856273 -73976183
Locus: 10q22.1
CDH23 Gene Summary
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
Gene Name: Cadherin Related 23
Chromosome: CHR10: 73156690 -73575704
Locus: 10q22.1
Gene Diseases
The ASCC1 CDH23 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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