ASAP1-KCNH1 Fusion FISH Probe
The ASAP1-KCNH1 Fusion FISH Probe is used to confirm a fusion of the ASAP1 and KCNH1 genes. The fusion of the ASAP1 and KCNH1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASAP1-KCNH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-RERE | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-REOR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-REGO | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-REGR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-REAQ | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-ORRE | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-OROR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-ORGO | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GORE | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GOOR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GOGO | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GOGR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GRRE | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GROR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GRGO | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GRGR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-AQRE | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-AQOR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-AQGO | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-AQGR | 20 (40 μL) | 200 μL |
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| ASAP1-KCNH1-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNH1 Gene Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily H Member 1
Chromosome: CHR1: 210851656 -211307457
Locus: 1q32.2
ASAP1 Gene Summary
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR8: 131064352 -131414217
Locus: 8q24.21-q24.22
Gene Diseases
The ASAP1 KCNH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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