ASAP1-CDKN2B Fusion FISH Probe
The ASAP1-CDKN2B Fusion FISH Probe is used to confirm a fusion of the ASAP1 and CDKN2B genes. The fusion of the ASAP1 and CDKN2B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ASAP1-CDKN2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-RERE | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-REOR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-REGO | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-REGR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-REAQ | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-ORRE | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-OROR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-ORGO | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GORE | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GOOR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GOGO | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GOGR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GRRE | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GROR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GRGO | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GRGR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-AQRE | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-AQOR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-AQGO | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-AQGR | 20 (40 μL) | 200 μL |
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| ASAP1-CDKN2B-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKN2B Gene Summary
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin Dependent Kinase Inhibitor 2B
Chromosome: CHR9: 22002901 -22009312
Locus: 9p21.3
ASAP1 Gene Summary
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR8: 131064352 -131414217
Locus: 8q24.21-q24.22
Gene Diseases
The ASAP1 CDKN2B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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