ARSB-DMGDH Fusion FISH Probe
The ARSB-DMGDH Fusion FISH Probe is used to confirm a fusion of the ARSB and DMGDH genes. The fusion of the ARSB and DMGDH genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARSB-DMGDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-RERE | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-REOR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-REGO | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-REGR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-REAQ | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-ORRE | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-OROR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-ORGO | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GORE | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GOOR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GOGO | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GOGR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GRRE | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GROR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GRGO | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GRGR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-AQRE | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-AQOR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-AQGO | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-AQGR | 20 (40 μL) | 200 μL |
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| ARSB-DMGDH-20-AQAQ | 20 (40 μL) | 200 μL |
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ARSB Gene Summary
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Gene Name: Arylsulfatase B
Chromosome: CHR5: 78073036 -78282357
Locus: 5q14.1
DMGDH Gene Summary
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Dimethylglycine Dehydrogenase
Chromosome: CHR5: 78293428 -78365449
Locus: 5q14.1
Gene Diseases
The ARSB DMGDH Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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