ARRB1-PRCP Fusion FISH Probe
The ARRB1-PRCP Fusion FISH Probe is used to confirm a fusion of the ARRB1 and PRCP genes. The fusion of the ARRB1 and PRCP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARRB1-PRCP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-PRCP-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
PRCP Gene Summary
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Prolylcarboxypeptidase
Chromosome: CHR11: 82535408 -82611557
Locus: 11q14.1
Gene Diseases
The ARRB1 PRCP Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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