ARRB1-PICALM Fusion FISH Probe
The ARRB1-PICALM Fusion FISH Probe is used to confirm a fusion of the ARRB1 and PICALM genes. The fusion of the ARRB1 and PICALM genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARRB1-PICALM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
PICALM Gene Summary
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome: CHR11: 85668213 -85780923
Locus: 11q14.2
Gene Diseases
The ARRB1 PICALM Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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