ARRB1-PAK1 Fusion FISH Probe
The ARRB1-PAK1 Fusion FISH Probe is used to confirm a fusion of the ARRB1 and PAK1 genes. The fusion of the ARRB1 and PAK1 genes has been associated with Breast Invasive Carcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARRB1-PAK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-PAK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
Gene Diseases
The ARRB1 PAK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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