ARRB1-GAB2 Fusion FISH Probe
The ARRB1-GAB2 Fusion FISH Probe is used to confirm a fusion of the ARRB1 and GAB2 genes. The fusion of the ARRB1 and GAB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARRB1-GAB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-GAB2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
GAB2 Gene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: GRB2 Associated Binding Protein 2
Chromosome: CHR11: 77926335 -78128868
Locus: 11q14.1
Gene Diseases
The ARRB1 GAB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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