ARRB1-DLG2 Fusion FISH Probe
The ARRB1-DLG2 Fusion FISH Probe is used to confirm a fusion of the ARRB1 and DLG2 genes. The fusion of the ARRB1 and DLG2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARRB1-DLG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-DLG2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARRB1 Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Name: Arrestin Beta 1
Chromosome: CHR11: 74971165 -75062875
Locus: 11q13.4
DLG2 Gene Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Gene Name: Discs Large MAGUK Scaffold Protein 2
Chromosome: CHR11: 83166055 -85338314
Locus: 11q14.1
Gene Diseases
The ARRB1 DLG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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