ARNTL2-ITPR2 Fusion FISH Probe
The ARNTL2-ITPR2 Fusion FISH Probe is used to confirm a fusion of the ARNTL2 and ITPR2 genes. The fusion of the ARNTL2 and ITPR2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARNTL2-ITPR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-RERE | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-REOR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-REGO | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-REGR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-OROR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GORE | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GROR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARNTL2-ITPR2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
ARNTL2 Gene Summary
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like 2
Chromosome: CHR12: 27485987 -27573466
Locus: 12p11.23
Gene Diseases
The ARNTL2 ITPR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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