ARNTL-TEAD1 Fusion FISH Probe
The ARNTL-TEAD1 Fusion FISH Probe is used to confirm a fusion of the ARNTL and TEAD1 genes. The fusion of the ARNTL and TEAD1 genes has been associated with Breast Invasive Carcinoma, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARNTL-TEAD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-RERE | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-REOR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-REGO | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-REGR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-OROR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GORE | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GROR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARNTL-TEAD1-20-AQAQ | 20 (40 μL) | 200 μL |
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ARNTL Gene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like
Chromosome: CHR11: 13299324 -13408812
Locus: 11p15.3
TEAD1 Gene Summary
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Gene Name: TEA Domain Transcription Factor 1
Chromosome: CHR11: 12695968 -12966284
Locus: 11p15.3
Gene Diseases
The ARNTL TEAD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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