ARNT2-MS4A3 Fusion FISH Probe
The ARNT2-MS4A3 Fusion FISH Probe is used to confirm a fusion of the ARNT2 and MS4A3 genes. The fusion of the ARNT2 and MS4A3 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARNT2-MS4A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-RERE | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-REOR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-REGO | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-REGR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-REAQ | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-ORRE | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-OROR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-ORGO | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GORE | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GOOR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GOGO | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GOGR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GRRE | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GROR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GRGO | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GRGR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-AQRE | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-AQOR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-AQGO | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-AQGR | 20 (40 μL) | 200 μL |
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| ARNT2-MS4A3-20-AQAQ | 20 (40 μL) | 200 μL |
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MS4A3 Gene Summary
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Name: Membrane Spanning 4-domains A3
Chromosome: CHR11: 59824100 -59838588
Locus: 11q12.1
ARNT2 Gene Summary
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator 2
Chromosome: CHR15: 80696691 -80890277
Locus: 15q25.1
Gene Diseases
The ARNT2 MS4A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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