ARNT-F5 Fusion FISH Probe
The ARNT-F5 Fusion FISH Probe is used to confirm a fusion of the ARNT and F5 genes. The fusion of the ARNT and F5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARNT-F5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-RERE | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-REOR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-REGO | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-REGR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-REAQ | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-ORRE | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-OROR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-ORGO | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GORE | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GOOR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GOGO | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GOGR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GRRE | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GROR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GRGO | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GRGR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-AQRE | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-AQOR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-AQGO | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-AQGR | 20 (40 μL) | 200 μL |
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| ARNT-F5-20-AQAQ | 20 (40 μL) | 200 μL |
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ARNT Gene Summary
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator
Chromosome: CHR1: 150782180 -150849244
Locus: 1q21.3
F5 Gene Summary
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
Gene Name: Coagulation Factor V
Chromosome: CHR1: 169481191 -169555769
Locus: 1q24.2
Gene Diseases
The ARNT F5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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