ARID4A-NPAS3 Fusion FISH Probe
The ARID4A-NPAS3 Fusion FISH Probe is used to confirm a fusion of the ARID4A and NPAS3 genes. The fusion of the ARID4A and NPAS3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARID4A-NPAS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ARID4A-NPAS3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ARID4A Gene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Name: AT-rich Interaction Domain 4A
Chromosome: CHR14: 58765221 -58840451
Locus: 14q23.1
NPAS3 Gene Summary
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Neuronal PAS Domain Protein 3
Chromosome: CHR14: 33408458 -34273382
Locus: 14q13.1
Gene Diseases
The ARID4A NPAS3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|