ARID1A-YTHDF2 Fusion FISH Probe
The ARID1A-YTHDF2 Fusion FISH Probe is used to confirm a fusion of the ARID1A and YTHDF2 genes. The fusion of the ARID1A and YTHDF2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARID1A-YTHDF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-RERE | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-REOR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-REGO | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-REGR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-REAQ | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-ORRE | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-OROR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-ORGO | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GORE | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GOOR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GOGO | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GOGR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GRRE | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GROR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GRGO | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GRGR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-AQRE | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-AQOR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-AQGO | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-AQGR | 20 (40 μL) | 200 μL |
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| ARID1A-YTHDF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARID1A Gene Summary
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: AT-rich Interaction Domain 1A
Chromosome: CHR1: 27022521 -27108601
Locus: 1p36.11
YTHDF2 Gene Summary
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Gene Name: YTH N6-methyladenosine RNA Binding Protein 2
Chromosome: CHR1: 29063132 -29096287
Locus: 1p35.3
Gene Diseases
The ARID1A YTHDF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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