ARID1A-NIPBL Fusion FISH Probe
The ARID1A-NIPBL Fusion FISH Probe is used to confirm a fusion of the ARID1A and NIPBL genes. The fusion of the ARID1A and NIPBL genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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ARID1A-NIPBL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-RERE | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-REOR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-REGO | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-REGR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-REAQ | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-ORRE | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-OROR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-ORGO | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-ORAQ | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GORE | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GOOR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GOGO | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GOGR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GOAQ | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GRRE | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GROR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GRGO | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GRGR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-GRAQ | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-AQRE | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-AQOR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-AQGO | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-AQGR | 20 (40 μL) | 200 μL | ||
ARID1A-NIPBL-20-AQAQ | 20 (40 μL) | 200 μL |
ARID1A Gene Summary
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: AT-rich Interaction Domain 1A
Chromosome: CHR1: 27022521 -27108601
Locus: 1p36.11
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The ARID1A NIPBL Fusion has been associated with the following diseases:
Disease Name |
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Lung Squamous Cell Carcinoma |
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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