ARHGEF3-ANO10 Fusion FISH Probe
The ARHGEF3-ANO10 Fusion FISH Probe is used to confirm a fusion of the ARHGEF3 and ANO10 genes. The fusion of the ARHGEF3 and ANO10 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF3-ANO10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF3-ANO10-20-AQAQ | 20 (40 μL) | 200 μL |
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ARHGEF3 Gene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 3
Chromosome: CHR3: 56761445 -57113336
Locus: 3p14.3
ANO10 Gene Summary
The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Anoctamin 10
Chromosome: CHR3: 43407817 -43663560
Locus: 3p22.1-p21.33
Gene Diseases
The ARHGEF3 ANO10 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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