ARHGEF12-POU2F3 Fusion FISH Probe
The ARHGEF12-POU2F3 Fusion FISH Probe is used to confirm a fusion of the ARHGEF12 and POU2F3 genes. The fusion of the ARHGEF12 and POU2F3 genes has been associated with Stomach Adenocarcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF12-POU2F3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF12-POU2F3-20-AQAQ | 20 (40 μL) | 200 μL |
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ARHGEF12 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Rho Guanine Nucleotide Exchange Factor 12
Chromosome: CHR11: 120207617 -120360645
Locus: 11q23.3
POU2F3 Gene Summary
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: POU Class 2 Homeobox 3
Chromosome: CHR11: 120110950 -120190653
Locus: 11q23.3
Gene Diseases
The ARHGEF12 POU2F3 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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