ARHGEF11-SHC1 Fusion FISH Probe
The ARHGEF11-SHC1 Fusion FISH Probe is used to confirm a fusion of the ARHGEF11 and SHC1 genes. The fusion of the ARHGEF11 and SHC1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF11-SHC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-SHC1-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
ARHGEF11 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 11
Chromosome: CHR1: 156904631 -157015162
Locus: 1q23.1
Gene Diseases
The ARHGEF11 SHC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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