ARHGEF11-CD48 Fusion FISH Probe
The ARHGEF11-CD48 Fusion FISH Probe is used to confirm a fusion of the ARHGEF11 and CD48 genes. The fusion of the ARHGEF11 and CD48 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF11-CD48-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF11-CD48-20-AQAQ | 20 (40 μL) | 200 μL |
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CD48 Gene Summary
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: CD48 Molecule
Chromosome: CHR1: 160648535 -160681585
Locus: 1q23.3
ARHGEF11 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Rho Guanine Nucleotide Exchange Factor 11
Chromosome: CHR1: 156904631 -157015162
Locus: 1q23.1
Gene Diseases
The ARHGEF11 CD48 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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