ARHGEF10L-PADI4 Fusion FISH Probe
The ARHGEF10L-PADI4 Fusion FISH Probe is used to confirm a fusion of the ARHGEF10L and PADI4 genes. The fusion of the ARHGEF10L and PADI4 genes has been associated with Lung Squamous Cell Carcinoma, Lung Adenocarcinoma, Breast Invasive Carcinoma, Bladder Urothelial Carcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGEF10L-PADI4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF10L-PADI4-20-AQAQ | 20 (40 μL) | 200 μL |
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PADI4 Gene Summary
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Gene Name: Peptidyl Arginine Deiminase 4
Chromosome: CHR1: 17634689 -17690495
Locus: 1p36.13
ARHGEF10L Gene Summary
This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
Gene Name: Rho Guanine Nucleotide Exchange Factor 10 Like
Chromosome: CHR1: 17866329 -18024370
Locus: 1p36.13
Gene Diseases
The ARHGEF10L PADI4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Bladder Urothelial Carcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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