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ARHGAP24-MAPK10 Fusion FISH Probe

The ARHGAP24-MAPK10 Fusion FISH Probe is used to confirm a fusion of the ARHGAP24 and MAPK10 genes. The fusion of the ARHGAP24 and MAPK10 genes has been associated with Prostate Adenocarcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ARHGAP24-MAPK10-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-RERE 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-REOR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-REGO 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-REGR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-REAQ 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-ORRE 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-OROR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-ORGO 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-ORAQ 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GORE 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GOOR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GOGO 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GOGR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GOAQ 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GRRE 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GROR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GRGO 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GRGR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-GRAQ 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-AQRE 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-AQOR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-AQGO 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-AQGR 20 (40 μL) 200 μL
ARHGAP24-MAPK10-20-AQAQ 20 (40 μL) 200 μL

MAPK10 Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Gene Name: Mitogen-activated Protein Kinase 10

Chromosome: CHR4: 86936275 -87374283

Locus: 4q21.3

ARHGAP24 Gene Summary

This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Gene Name: Rho GTPase Activating Protein 24

Chromosome: CHR4: 86396283 -86923823

Locus: 4q21.23-q21.3

Gene Diseases

The ARHGAP24 MAPK10 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.