ARAP1-FADD Fusion FISH Probe
The ARAP1-FADD Fusion FISH Probe is used to confirm a fusion of the ARAP1 and FADD genes. The fusion of the ARAP1 and FADD genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARAP1-FADD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-RERE | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-REOR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-REGO | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-REGR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-REAQ | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-ORRE | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-OROR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-ORGO | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GORE | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GOOR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GOGO | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GOGR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GRRE | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GROR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GRGO | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GRGR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-AQRE | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-AQOR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-AQGO | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-AQGR | 20 (40 μL) | 200 μL |
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| ARAP1-FADD-20-AQAQ | 20 (40 μL) | 200 μL |
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FADD Gene Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Gene Name: Fas Associated Via Death Domain
Chromosome: CHR11: 70049268 -70053508
Locus: 11q13.3
ARAP1 Gene Summary
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR11: 72396113 -72463434
Locus: 11q13.4
Gene Diseases
The ARAP1 FADD Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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