AR-NR4A3 Fusion FISH Probe
The AR-NR4A3 Fusion FISH Probe is used to confirm a fusion of the AR and NR4A3 genes. The fusion of the AR and NR4A3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AR-NR4A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-RERE | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-REOR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-REGO | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-REGR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-REAQ | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-ORRE | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-OROR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-ORGO | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GORE | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GOOR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GOGO | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GOGR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GRRE | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GROR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GRGO | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GRGR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-AQRE | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-AQOR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-AQGO | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-AQGR | 20 (40 μL) | 200 μL |
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| AR-NR4A3-20-AQAQ | 20 (40 μL) | 200 μL |
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AR Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Androgen Receptor
Chromosome: CHRX: 66763873 -66944119
Locus: Xq12
NR4A3 Gene Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Nuclear Receptor Subfamily 4 Group A Member 3
Chromosome: CHR9: 102584136 -102629173
Locus: 9q31.1
Gene Diseases
The AR NR4A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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