APPL2-NR0B1 Fusion FISH Probe
The APPL2-NR0B1 Fusion FISH Probe is used to confirm a fusion of the APPL2 and NR0B1 genes. The fusion of the APPL2 and NR0B1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APPL2-NR0B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| APPL2-NR0B1-20-AQAQ | 20 (40 μL) | 200 μL |
|
NR0B1 Gene Summary
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Subfamily 0 Group B Member 1
Chromosome: CHRX: 30322538 -30327495
Locus: Xp21.2
APPL2 Gene Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Gene Name: Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2
Chromosome: CHR12: 105567074 -105630008
Locus: 12q23.3
Gene Diseases
The APPL2 NR0B1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|