APPBP2-WISP2 Fusion FISH Probe
The APPBP2-WISP2 Fusion FISH Probe is used to confirm a fusion of the APPBP2 and WISP2 genes. The fusion of the APPBP2 and WISP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APPBP2-WISP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-RERE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-OROR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GORE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GROR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQAQ | 20 (40 μL) | 200 μL |
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WISP2 Gene Summary
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
Gene Name: WNT1 Inducible Signaling Pathway Protein 2
Chromosome: CHR20: 43343884 -43356452
Locus: 20q13.12
APPBP2 Gene Summary
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Amyloid Beta Precursor Protein Binding Protein 2
Chromosome: CHR17: 58520519 -58603580
Locus: 17q23.2
Gene Diseases
The APPBP2 WISP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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