APP-SEC63 Fusion FISH Probe
The APP-SEC63 Fusion FISH Probe is used to confirm a fusion of the APP and SEC63 genes. The fusion of the APP and SEC63 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APP-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| APP-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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APP Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860 -27543446
Locus: 21q21.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The APP SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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