APP-CCT8 Fusion FISH Probe
The APP-CCT8 Fusion FISH Probe is used to confirm a fusion of the APP and CCT8 genes. The fusion of the APP and CCT8 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APP-CCT8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-RERE | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-REOR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-REGO | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-REGR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-REAQ | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-ORRE | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-OROR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-ORGO | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-ORAQ | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GORE | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GOOR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GOGO | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GOGR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GOAQ | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GRRE | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GROR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GRGO | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GRGR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-GRAQ | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-AQRE | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-AQOR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-AQGO | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-AQGR | 20 (40 μL) | 200 μL |
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| APP-CCT8-20-AQAQ | 20 (40 μL) | 200 μL |
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APP Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860 -27543446
Locus: 21q21.3
CCT8 Gene Summary
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Gene Name: Chaperonin Containing TCP1 Subunit 8
Chromosome: CHR21: 30428647 -30446010
Locus: 21q21.3
Gene Diseases
The APP CCT8 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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