APOE-CCT5 Fusion FISH Probe
The APOE-CCT5 Fusion FISH Probe is used to confirm a fusion of the APOE and CCT5 genes. The fusion of the APOE and CCT5 genes has been associated with Kidney Renal Clear Cell Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APOE-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| APOE-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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APOE Gene Summary
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Gene Name: Apolipoprotein E
Chromosome: CHR19: 45409038 -45412650
Locus: 19q13.32
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The APOE CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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