APOE-ARFGEF2 Fusion FISH Probe
The APOE-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the APOE and ARFGEF2 genes. The fusion of the APOE and ARFGEF2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APOE-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| APOE-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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APOE Gene Summary
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Gene Name: Apolipoprotein E
Chromosome: CHR19: 45409038 -45412650
Locus: 19q13.32
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The APOE ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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