APLP2-TYK2 Fusion FISH Probe
The APLP2-TYK2 Fusion FISH Probe is used to confirm a fusion of the APLP2 and TYK2 genes. The fusion of the APLP2 and TYK2 genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APLP2-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| APLP2-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The APLP2 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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