APLP2-PLEKHA5 Fusion FISH Probe
The APLP2-PLEKHA5 Fusion FISH Probe is used to confirm a fusion of the APLP2 and PLEKHA5 genes. The fusion of the APLP2 and PLEKHA5 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APLP2-PLEKHA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-RERE | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-REOR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-REGO | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-REGR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-REAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-ORRE | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-OROR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-ORGO | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GORE | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GOOR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GOGO | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GOGR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GRRE | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GROR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GRGO | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GRGR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-AQRE | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-AQOR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-AQGO | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-AQGR | 20 (40 μL) | 200 μL |
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| APLP2-PLEKHA5-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
PLEKHA5 Gene Summary
The Pleckstrin Homology Domain Containing A5 (PLEKHA5) gene is located on chr12 :19282625-19529333 at 12p12.3.
Gene Name: Pleckstrin Homology Domain Containing A5
Chromosome: CHR12: 19282625 -19529333
Locus: 12p12.3
Gene Diseases
The APLP2 PLEKHA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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