APLP2-EIF2AK2 Fusion FISH Probe
The APLP2-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the APLP2 and EIF2AK2 genes. The fusion of the APLP2 and EIF2AK2 genes has been associated with Lung Adenocarcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APLP2-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| APLP2-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The APLP2 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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