APLP2-CD40 Fusion FISH Probe
The APLP2-CD40 Fusion FISH Probe is used to confirm a fusion of the APLP2 and CD40 genes. The fusion of the APLP2 and CD40 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APLP2-CD40-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-RERE | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-REOR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-REGO | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-REGR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-REAQ | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-ORRE | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-OROR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-ORGO | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-ORAQ | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GORE | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GOOR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GOGO | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GOGR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GOAQ | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GRRE | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GROR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GRGO | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GRGR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-GRAQ | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-AQRE | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-AQOR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-AQGO | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-AQGR | 20 (40 μL) | 200 μL |
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| APLP2-CD40-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
CD40 Gene Summary
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Gene Name: CD40 Molecule
Chromosome: CHR20: 44746905 -44758384
Locus: 20q13.12
Gene Diseases
The APLP2 CD40 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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