API5-GANC Fusion FISH Probe
The API5-GANC Fusion FISH Probe is used to confirm a fusion of the API5 and GANC genes. The fusion of the API5 and GANC genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| API5-GANC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| API5-GANC-20-RERE | 20 (40 μL) | 200 μL |
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| API5-GANC-20-REOR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-REGO | 20 (40 μL) | 200 μL |
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| API5-GANC-20-REGR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-REAQ | 20 (40 μL) | 200 μL |
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| API5-GANC-20-ORRE | 20 (40 μL) | 200 μL |
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| API5-GANC-20-OROR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-ORGO | 20 (40 μL) | 200 μL |
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| API5-GANC-20-ORAQ | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GORE | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GOOR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GOGO | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GOGR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GOAQ | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GRRE | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GROR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GRGO | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GRGR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-GRAQ | 20 (40 μL) | 200 μL |
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| API5-GANC-20-AQRE | 20 (40 μL) | 200 μL |
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| API5-GANC-20-AQOR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-AQGO | 20 (40 μL) | 200 μL |
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| API5-GANC-20-AQGR | 20 (40 μL) | 200 μL |
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| API5-GANC-20-AQAQ | 20 (40 μL) | 200 μL |
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GANC Gene Summary
Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]
Gene Name: Glucosidase Alpha, Neutral C
Chromosome: CHR15: 42566365 -42645864
Locus: 15q15.1
API5 Gene Summary
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Apoptosis Inhibitor 5
Chromosome: CHR11: 43333504 -43366080
Locus: 11p12
Gene Diseases
The API5 GANC Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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