APH1A-SLAMF1 Fusion FISH Probe
The APH1A-SLAMF1 Fusion FISH Probe is used to confirm a fusion of the APH1A and SLAMF1 genes. The fusion of the APH1A and SLAMF1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APH1A-SLAMF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-RERE | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-REOR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-REGO | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-REGR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-REAQ | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-ORRE | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-OROR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-ORGO | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GORE | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GOOR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GOGO | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GOGR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GRRE | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GROR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GRGO | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GRGR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-AQRE | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-AQOR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-AQGO | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-AQGR | 20 (40 μL) | 200 μL |
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| APH1A-SLAMF1-20-AQAQ | 20 (40 μL) | 200 μL |
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SLAMF1 Gene Summary
The Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) gene is located on chr1 :160579890-160617081 at 1q23.3.
Gene Name: Signaling Lymphocytic Activation Molecule Family Member 1
Chromosome: CHR1: 160579890 -160617081
Locus: 1q23.3
APH1A Gene Summary
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Aph-1 Homolog A, Gamma-secretase Subunit
Chromosome: CHR1: 150237798 -150241609
Locus: 1q21.2
Gene Diseases
The APH1A SLAMF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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