APC2-GIGYF2 Fusion FISH Probe
The APC2-GIGYF2 Fusion FISH Probe is used to confirm a fusion of the APC2 and GIGYF2 genes. The fusion of the APC2 and GIGYF2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APC2-GIGYF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-RERE | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-REOR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-REGO | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-REGR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-REAQ | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-ORRE | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-OROR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-ORGO | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GORE | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GOOR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GOGO | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GOGR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GRRE | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GROR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GRGO | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GRGR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-AQRE | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-AQOR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-AQGO | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-AQGR | 20 (40 μL) | 200 μL |
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| APC2-GIGYF2-20-AQAQ | 20 (40 μL) | 200 μL |
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APC2 Gene Summary
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Gene Name: APC2, WNT Signaling Pathway Regulator
Chromosome: CHR19: 1450147 -1473243
Locus: 19p13.3
GIGYF2 Gene Summary
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: GRB10 Interacting GYF Protein 2
Chromosome: CHR2: 233562014 -233725289
Locus: 2q37.1
Gene Diseases
The APC2 GIGYF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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