APBA1-RAD23B Fusion FISH Probe
The APBA1-RAD23B Fusion FISH Probe is used to confirm a fusion of the APBA1 and RAD23B genes. The fusion of the APBA1 and RAD23B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APBA1-RAD23B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-RERE | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-REOR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-REGO | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-REGR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-REAQ | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-ORRE | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-OROR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-ORGO | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-ORAQ | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GORE | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GOOR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GOGO | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GOGR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GOAQ | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GRRE | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GROR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GRGO | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GRGR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-GRAQ | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-AQRE | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-AQOR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-AQGO | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-AQGR | 20 (40 μL) | 200 μL |
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| APBA1-RAD23B-20-AQAQ | 20 (40 μL) | 200 μL |
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APBA1 Gene Summary
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
Gene Name: Amyloid Beta Precursor Protein Binding Family A Member 1
Chromosome: CHR9: 72042448 -72287275
Locus: 9q21.12
RAD23B Gene Summary
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
Gene Name: RAD23 Homolog B, Nucleotide Excision Repair Protein
Chromosome: CHR9: 110045543 -110094470
Locus: 9q31.2
Gene Diseases
The APBA1 RAD23B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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