APAF1-HOXC10 Fusion FISH Probe
The APAF1-HOXC10 Fusion FISH Probe is used to confirm a fusion of the APAF1 and HOXC10 genes. The fusion of the APAF1 and HOXC10 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APAF1-HOXC10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-RERE | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-REOR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-REGO | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-REGR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-REAQ | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-ORRE | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-OROR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-ORGO | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-ORAQ | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GORE | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GOOR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GOGO | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GOGR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GOAQ | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GRRE | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GROR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GRGO | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GRGR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-GRAQ | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-AQRE | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-AQOR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-AQGO | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-AQGR | 20 (40 μL) | 200 μL |
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| APAF1-HOXC10-20-AQAQ | 20 (40 μL) | 200 μL |
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APAF1 Gene Summary
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Apoptotic Peptidase Activating Factor 1
Chromosome: CHR12: 99039077 -99129211
Locus: 12q23.1
HOXC10 Gene Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Gene Name: Homeobox C10
Chromosome: CHR12: 54378945 -54384062
Locus: 12q13.13
Gene Diseases
The APAF1 HOXC10 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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