AP3B1-IPO11 Fusion FISH Probe
The AP3B1-IPO11 Fusion FISH Probe is used to confirm a fusion of the AP3B1 and IPO11 genes. The fusion of the AP3B1 and IPO11 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP3B1-IPO11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-RERE | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-REOR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-REGO | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-REGR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-REAQ | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-ORRE | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-OROR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-ORGO | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GORE | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GOOR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GOGO | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GOGR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GRRE | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GROR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GRGO | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GRGR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-AQRE | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-AQOR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-AQGO | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-AQGR | 20 (40 μL) | 200 μL |
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| AP3B1-IPO11-20-AQAQ | 20 (40 μL) | 200 μL |
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AP3B1 Gene Summary
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Name: Adaptor Related Protein Complex 3 Beta 1 Subunit
Chromosome: CHR5: 77298149 -77590528
Locus: 5q14.1
IPO11 Gene Summary
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Gene Name: Importin 11
Chromosome: CHR5: 61708572 -61924416
Locus: 5q12.1
Gene Diseases
The AP3B1 IPO11 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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