AP3B1-CAMLG Fusion FISH Probe
The AP3B1-CAMLG Fusion FISH Probe is used to confirm a fusion of the AP3B1 and CAMLG genes. The fusion of the AP3B1 and CAMLG genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP3B1-CAMLG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-RERE | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-REOR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-REGO | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-REGR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-REAQ | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-ORRE | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-OROR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-ORGO | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GORE | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GOOR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GOGO | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GOGR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GRRE | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GROR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GRGO | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GRGR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-AQRE | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-AQOR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-AQGO | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-AQGR | 20 (40 μL) | 200 μL |
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| AP3B1-CAMLG-20-AQAQ | 20 (40 μL) | 200 μL |
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CAMLG Gene Summary
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Modulating Ligand
Chromosome: CHR5: 134074169 -134087850
Locus: 5q31.1
AP3B1 Gene Summary
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Name: Adaptor Related Protein Complex 3 Beta 1 Subunit
Chromosome: CHR5: 77298149 -77590528
Locus: 5q14.1
Gene Diseases
The AP3B1 CAMLG Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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