AP2M1-TYK2 Fusion FISH Probe
The AP2M1-TYK2 Fusion FISH Probe is used to confirm a fusion of the AP2M1 and TYK2 genes. The fusion of the AP2M1 and TYK2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP2M1-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| AP2M1-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2M1 Gene Summary
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Gene Name: Adaptor Related Protein Complex 2 Mu 1 Subunit
Chromosome: CHR3: 183892633 -183901879
Locus: 3q27.1
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The AP2M1 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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